Lymphoma Immunophenotyping: A New Era in Paraffin-Section Immunohistochemistry
作者:
Eric Hsi,
Subramanian Yegappan,
期刊:
Advances in Anatomic Pathology
(OVID Available online 2001)
卷期:
Volume 8,
issue 4
页码: 218-239
ISSN:1072-4109
年代: 2001
出版商: OVID
关键词: Immunohistochemistry;Lymphoma;Non-Hodgkin lymphoma;Hodgkin lymphoma;Heat-induced epitope retrieval;Monoclonal antibody
数据来源: OVID
摘要:
Recent advances in immunohistochemistry have made it possible to investigate lymphomas for the expression of a wide range of antigens in fixed tissues. Epitope retrieval, sensitive detection methods, and the availability of new monoclonal antibodies have all contributed to one's ability to perform detailed immunophenotyping that previously could only be done in cryostat sections or by flow cytometry. Current lymphoma classifications make use of characteristic immunophenotypic profiles that aid in the reproducible diagnosis and subcassification of these neoplasms. The following is a review of the current state of immunophenotyping for lymphoid neoplasms in fixed tissues.
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