DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism
作者:
Steven W. Matson,
Daniel W. Bean,
James W. George,
期刊:
BioEssays
(WILEY Available online 1994)
卷期:
Volume 16,
issue 1
页码: 13-22
ISSN:0265-9247
年代: 1994
DOI:10.1002/bies.950160103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractDNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double‐stranded DNA together. This energy‐requiring unwinding reaction results in the formation of the single‐stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination. A combination of biochemical and genetic studies have been used to probe and define the roles of the multiple DNA helicases found inE. coli.This work and similar efforts in eukaryotic cells, although far from complete, have established that DNA helicases are essential components of the machinery that interacts with the DNA mol
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