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Immune-Type Glomerulonephritis Induced in the Brown-Norway Rat with Mercury-Containing Pharmaceutical Products

 

作者: P. Druet,   P. Teychenne,   C. Mandet,   C. Bascou,   E. Druet,  

 

期刊: Nephron  （Karger Available online 1981）
卷期: Volume 28, issue 3  

页码: 145-148

 

ISSN:1660-8151

 

年代: 1981

 

DOI:10.1159/000182136

 

出版商: S. Karger AG

 

关键词: Glomerulonephritis;Mercury;Immune complexes;Basement membrane;Rat

 

数据来源: Karger

 

摘要:

It has been shown that Brown-Norway rats develop an immune-type glomerulonephritis after treatment with various mercury-containing drugs. Anti-GBM antibodies were involved, at least in some animals. This glomerulonephritis induced a proteinuria. Strong evidence is given, suggesting that most mercury compounds, some of which, such as mercurial antiseptics, are widely used, could induce an immune-type glomerulonephritis. The question therefore arises, whether these drugs can be used any longer.

 

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