Mechanisms of Irritative Activity of Compound 48/80 on Rat Gastric Mucosa
作者:
K. Takeuchi,
H. Ohtsuki,
Y. Nobuhara,
S. Okabe,
期刊:
Digestion
(Karger Available online 1986)
卷期:
Volume 33,
issue 1
页码: 34-44
ISSN:0012-2823
年代: 1986
DOI:10.1159/000199272
出版商: S. Karger AG
关键词: Compound 48/80;Gastric PD;pH;luminal;Lesion;gastric;Histamine;Serotonin;Rat;anesthetized
数据来源: Karger
摘要:
A single intraperitoneal injection of compound 48/80 (48/80) (0.5–3 mg/kg) into anesthetized rats caused a dose-dependent reduction of the transmucosal potential difference (PD) and intraluminal pH (pH), and induced gastric lesions within 2 h. These same changes were seen with an intraperitoneal injection of histamine, but not with serotonin. There was a significant correlation between the lesion index and the PD reduction, although the integrity of the resting gastric mucosal barrier remained unaltered. The PD reduction caused by 48/80 was dose-dependently inhibited by tripelennamine (H1-antagonist) and FPL-52694 (mast cell stabilizer) and partially suppressed by methysergide (serotonin antagonist), but the changes in pH were prevented by FPL-52964 and cimetidine (H2-antagonist). The reduction of PD and pH induced by histamine was inhibited by tripelennamine or cimetidine, respectively, but these responses were not inhibited by FPL-52694 or methysergide. Gastric lesions induced by 48/80 were potently inhibited by tripelennamine and FPL-52694, and partially by cimetidine, whereas those induced by histamine were significantly prevented by tripelennamine and cimetidine, but not by FPL-52694. Methysergide had no effect on the development of gastric lesions in response to 48/80 or histamine. These results suggest that a single injection of 48/80 reduced the PD and stimulated acid secretion, thereby producing gastric lesions. These effects of 48/80 may be due to activation of H1 and H2-receptors by acutely released endogenous histamin
点击下载:
PDF
(1276KB)
返 回