The effect of maleic hydrazide treatment on the contents of total and non‐protein nitrogen, protein and minerals was assessed on cortex and pith tissues of two potato varieties (Katahdin and Kennebec) grown at two locations (Long Island and Ithaca, NY). Maleic hydrazide significantly increased (p<0.01) the total and non‐protein nitrogen of cortex tissue but showed no significant effect on protein and mineral contents. Sprouts and bud tissue from Katahdin and Kennebec tubers grown at Ithaca were assessed for mineral composition. In both varieties the amounts of calcium, magnesium, manganese and zinc in sprouts were significantly increased (p<0.01) by maleic hydrazide treatment. No significant effect of MH on mineral content of bud tissue was obser