Preparation and evaluation of cationic99Tc/99mTc dimethoxy‐ and diethoxy‐hexanedione dioxime complexes
作者:
Z. F. Su,
K. H. Linse,
H. J. Steinmetz,
K. Schwochau,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1992)
卷期:
Volume 31,
issue 1
页码: 61-70
ISSN:0362-4803
年代: 1992
DOI:10.1002/jlcr.2580310108
出版商: John Wiley&Sons, Ltd.
关键词: technetium;cationic dioxime complexes;lipophilicity;biodistribution
数据来源: WILEY
摘要:
AbstractThe new ligands 1,6‐dimethoxy‐3,4‐hexanedione dioxime (DMHD) and 1,6‐diethoxy‐3,4‐hexanedione dioxime (DEHD) were synthesized and their boron containing99Tc/99mTc complexes, formed by reduction of pertechnetate with BH4‐, were isolated, purified and characterized by IR/UV/VIS spectroscopy and FAB mass spectrometry. These rather stable cationic complexes differ significantly in lipophilicity as assessed by their octanol/saline partition coefficients and HPLC capacity factors. Unexpectedly the organ uptake and clearance of both complexes in mice proved to be very similar with only the uptake of99mTc‐DMHD in the kidneys
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