BackgroundIntra‐ and postoperative clinical properties of sciatic‐femoral nerve block performed with either ropivacaine at different concentrations or mepivacaine have been evaluated in a multicenter, randomized, blinded study.MethodsAdult patients scheduled for foot and ankle surgery were randomized to receive combined sciatic‐femoral nerve block with 225 mg of either 0.5% (n = 83), 0.75% (n = 87), or 1% (n = 86) ropivacaine, or with 500 mg of 2% mepivacaine (n = 84). A thigh tourniquet was used in all patients. Onset time, adequacy of surgical anesthesia, time to offset of nerve block, and time until first postoperative requirement for pain medication were evaluated by a blinded observer.ResultsThe adequacy of nerve block was similar in the four treatment groups (the ratios between adequate:inadequate: failed blocks were 74:9:0 with 0.5% ropivacaine, 74:13:0 with 0.75% ropivacaine, 78:8:0 with 1% ropivacaine, and 72:12:0 with 2% mepivacaine). The onset of the block was slower with 0.5% ropivacaine than with other anesthetic solutions (P < 0.001). Regardless of the concentration, ropivacaine produced a longer motor blockade (10.5 +/− 3.8 h, 10.3 +/− 4.3 h, and 10.2 +/− 5.1 h with 0.5%, 0.75%, and 1% ropivacaine, respectively) than with mepivacaine (4.3 +/− 2.6 h; P < 0.001). The duration of postoperative analgesia was shorter after mepivacaine (5.1 +/− 2.7 h) than after ropivacaine (12.2 +/− 4.1 h, 14.3 +/− 5 h, and 14.5 +/− 3.4 h, with 0.5%, 0.75%, or 1% ropivacaine, respectively; P < 0.001). Pain relief after 0.5% ropivacaine was 14% shorter than 0.75% or 1% ropivacaine (P < 0.05). During the first 24 h after surgery, 30‐37% of patients receiving ropivacaine required no analgesics compared with 10% of those receiving mepivacaine (P < 0.001).ConclusionsThis study suggests that 0.75% ropivacaine is the most suitable choice of local anesthetic for combined sciatic‐femoral nerve block, providing an onset similar to mepivacaine and prolonged postoperative analgesia.