Transient myeloproliferative disorder in chromosomally normal newborn infant
作者:
D. K. Kalousek,
K. W. Chan,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1987)
卷期:
Volume 15,
issue 1
页码: 38-41
ISSN:0098-1532
年代: 1987
DOI:10.1002/mpo.2950150109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: trisomy 21;confined placental mosaicism
数据来源: WILEY
摘要:
AbstractTransient Myeloproliferative disorder is a condition clinically resembling congenital acute myelogenous leukemia. As in acute leukemias the blast cell population in this disorder may have either normal or abnormal chromosomal complement. Transient myeloproliferative disorder is well recognized in neonates with a complete or mosaic trisomy 21 (Down's syndrome). We report a phenotypically and cytogenetically normal infant with this syndrome in whom only blast cells showed trisomy 21. We postulate that the pathogenesis of the transient myeloproliferative disorder in both Down's syndrome infants and those with a normal chromosomal complement is related to abnormal prenatal production of placental regulatory hemopoietic factors caused by chromosomal defect(s) confined to placental tissues.
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