COMPARISON OF THE EFFECTS OF UV‐VISIBLE IRRADIATION OF MELANINS and MELANIN‐HEMATOPORPHYRIN COMPLEXES FROM HUMAN BLACK and RED HAIR
作者:
Surujdeen Persad,
I. Aravindakshan Menon,
Herbert F. Haberman,
期刊:
Photochemistry and Photobiology
(WILEY Available online 1983)
卷期:
Volume 37,
issue 1
页码: 63-68
ISSN:0031-8655
年代: 1983
DOI:10.1111/j.1751-1097.1983.tb04434.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractClinical evidence indicates that people with light skin and red hair have a higher incidence of UV radiation‐induced diseases including cancer. It is not known whether this is because of the lower protection due to the smaller amounts of eumelanin present in the skin of these people or whether the presence of pheomelanin in their skin is responsible for the higher susceptibility to carcinogenesis. Irradiation of melanoproteins from red hair with UV‐visible light has been reported to produce superoxide. Comparative studies on the formation of superoxide during the irradiation of the melanins isolated from human black and red hair (BHM and RHM, respectively) are reported in this paper. These showed that no superoxide formation could be detected in the case of the BHM. whereas the formation of superoxide during the irradiation of RHM could be definitely demonstrated. Irradiation of the RHM with NADH resulted in the oxidation of more NADH than the irradiation of NADH with BHM. The observation that RHM is an active photosensitizer indicates that this property of pheomelanin present in light skin may at least partly be responsible for the harmful effect of radiation on people with light skin and/or red hair. Administration of hematoporphyrin followed by visible irradiation is a currently used mode of therapy for cancer. The present studies have shown that hematoporphyrin is bound to both BHM and RHM. The binding of hematoporphyrin to the melanins increased the formation of superoxide by RHM and the oxidation of NADH by both the melanins. The binding of porphyrins to melanins may have an influence upon the photosensitivity in diseases such as porphyrias and may also affect the therapeutic efficacy of hematoporphy
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