Polymetallic macromolecules are potential contrast agents of improved efficiency
作者:
Frederich Cavagna,
Claudio Luchinat,
Andrea Scozzafava,
Zhicheng Xia,
期刊:
Magnetic Resonance in Medicine
(WILEY Available online 1994)
卷期:
Volume 31,
issue 1
页码: 58-60
ISSN:0740-3194
年代: 1994
DOI:10.1002/mrm.1910310109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: polymetallic contrast agents;gadolinium polyaspartate
数据来源: WILEY
摘要:
AbstractThe commercial synthetic homopolypeptide polyaspartate (average MW = 30,000, approximately 220 monomers) in solution quantitatively binds up to 40 mol Gd2+ions per mole of polyaspartate. The water proton relaxivity of the solutions is far higher than that of clinically used or commonly investigated gadolinium(III) complexes. It is shown that polymetallic macromolecular complexes combine the high relaxing efficiency of monometallic macromolecular complexes with the favorable metal/ligand mass ratio of small monometallic complexes.
点击下载:
PDF
(285KB)
返 回