DNA Antibody Idiotypes: An Analysis of Their Clinical Connections and Origins
作者:
WattsRichard,
IsenbergDavid,
期刊:
International Reviews of Immunology
(Taylor Available online 1990)
卷期:
Volume 5,
issue 3-4
页码: 279-293
ISSN:0883-0185
年代: 1990
DOI:10.3109/08830189009056735
出版商: Taylor&Francis
关键词: idiotype;systemic lupus erythematosus;anti-DNA antibodies
数据来源: Taylor
摘要:
Approximately thirty common DNA antibody idiotypes have been described on hybridoma derived or affinity purified DNA-binding antibodies. There are associations between some idiotypes and the clinical manifestations of systemic lupus erythematosus although none are sufficiently firm to be clinically useful in identifying subsets of SLE or in assessing disease activity in individual patients. The expression of these idiotypes is not confined to DNA antibodies in SLE. They may be found in the serum from patients with a range of autoimmune rheumatic disorders, infectious diseases and blood dyscrasias. In most cases the antigen binding specificity of the antibody bearing the idiotype is unknown. The precise relationship between the various idiotypes is becoming better understood with increasing availability of genetic and structural data. DNA antibody idiotype manipulation may provide a potential new therapeutic modality in SLE.
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