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Naloxone-Induced Dissociation of Oxytocin and Prolactin Releases

 

作者: Willis K. Samson,   John K. McDonald,   Michael D. Lumpkin,  

 

期刊: Neuroendocrinology  (Karger Available online 1985)
卷期: Volume 40, issue 1  

页码: 68-71

 

ISSN:0028-3835

 

年代: 1985

 

DOI:10.1159/000124053

 

出版商: S. Karger AG

 

关键词: Oxytocin;Prolactin;Stress;Naloxone

 

数据来源: Karger

 

摘要:

Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT release was observed. These results demonstrate that concomitant releases of OT and PRL in response to a given physiologic stimulus (stress) can be dissociated and suggest that the hypothalamic events which are responsible for the release of these hormones during stress are different.

 

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