Naloxone-Induced Dissociation of Oxytocin and Prolactin Releases
作者:
Willis K. Samson,
John K. McDonald,
Michael D. Lumpkin,
期刊:
Neuroendocrinology
(Karger Available online 1985)
卷期:
Volume 40,
issue 1
页码: 68-71
ISSN:0028-3835
年代: 1985
DOI:10.1159/000124053
出版商: S. Karger AG
关键词: Oxytocin;Prolactin;Stress;Naloxone
数据来源: Karger
摘要:
Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT release was observed. These results demonstrate that concomitant releases of OT and PRL in response to a given physiologic stimulus (stress) can be dissociated and suggest that the hypothalamic events which are responsible for the release of these hormones during stress are different.
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