Molecular recognition: Model studies with convergent functional groups
作者:
Julius Rebek,
期刊:
Journal of Molecular Recognition
(WILEY Available online 1988)
卷期:
Volume 1,
issue 1
页码: 1-8
ISSN:0952-3499
年代: 1988
DOI:10.1002/jmr.300010103
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractModel studies of molecular recognition are reviewed with emphasis on contributions from macrocyclic chemistry. Recent developments concerning new molecular shapes are discussed. The advantages of a molecular cleft are presented. In these structures functional groups converge to create a microenvironment complementary to substrates. Specifically, di‐, tri‐ and tetracarboxylic acids of varying sizes are shown to recognize smaller molecules of complementary shape. The new receptors function by a combination of hydrogen bonding and aryl stacking interactions. Substrates include amines, acids, amino acids, metal ions and nucleotide components. The relationship between functional group orientation and catalysis is explored and two systems capable of concerted acid/base catalysis are introdu
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