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Platelet-Reactivity of Isolated Constituents of the Blood Vessel Wall

 

作者: M.J. Barnes,   D.E. Maclntyre,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  (Karger Available online 1979)
卷期: Volume 8, issue 3-5  

页码: 158-170

 

ISSN:1424-8832

 

年代: 1979

 

DOI:10.1159/000214308

 

出版商: S. Karger AG

 

关键词: Arterial collagens;Collagen polymorphism;Platelet aggregation;Platelet adhesion;Elastin;Microfibrillar protein

 

数据来源: Karger

 

摘要:

Collagens I and III, in fibrillar form, bound platelets equally well; both readily induced platelet aggregation. In contrast, collagens IV and V, although pretreated as collagens I and III to induce fibrillogenesis, failed to produce aggregation. No binding of platelets was detected. Lens capsule, containing collagen type IV in situ, was also inactive. Inactivity appears due to the lack of an appropriate quaternary structure since segment-long-spacing (SLS) aggregates of collagens IV and V, as of type I, induced aggregation. Elastin and its associated microfibrillar element did not aggregate platelets; some binding of platelets to elastin only was observed.

 

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