Derivatization‐Gas Chromatographic Analysis of Nalidixic Acid in Tablets
作者:
Shou‐Mei Wu,
Hsin‐Lung Wu,
Su‐Hwei Chen,
期刊:
Journal of the Chinese Chemical Society
(WILEY Available online 1987)
卷期:
Volume 34,
issue 1
页码: 7-11
ISSN:0009-4536
年代: 1987
DOI:10.1002/jccs.198700002
出版商: WILEY‐VCH Verlag
关键词: Nalidixic acid;pentafluorobenzyl derivative;derivatization‐gas chromatography
数据来源: WILEY
摘要:
AbstractA simple and improved gas chromatographic method has been developed for the quantitative analysis of nalidixic acid. The method is based on the derivatization of nalidixic acid with pentafluorobenzyl bromide in acetone, using potassium carbonate as a base‐catalyst. The derivative obtained was chromatographed on an OV‐101 column and the pentafluorobenzyl ester of cinoxacin was used as an internal standard. The method was satisfactorily applied to the analysis of nalidixic acid in tablets, and the results agree well with those obtained using the UV absorption spectrophotometric met
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