The pleckstrin homology domain: An intriguing multifunctional protein module
作者:
Gerry Shaw,
期刊:
BioEssays
(WILEY Available online 1996)
卷期:
Volume 18,
issue 1
页码: 35-46
ISSN:0265-9247
年代: 1996
DOI:10.1002/bies.950180109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPleckstrin homology (PH) domains are a family of compact protein modules defined by sequences of roughly 100 amino acids. These domains are common in vertebrate,Drosophila, C. elegansand yeast proteins, suggesting an early origin and fundamental importance to eukaryotic biology. Many enzymes which have important regulatory functions contain PH domains, and mutant forms of several such proteins are implicated in oncogenesis and developmental disorders. Numerous recent studies show that PH domains bind various proteins and inositolphosphates. Here I discuss PH domains in detail and conclude that they form a versatile family of membrane binding and protein localization modules.
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