Intersection of a moving edge dislocation with disclination configurations, an isolated wedge disclination and a quadrupole of wedge disclinations, is theoretically examined in detail. It is shown that, after a moving disclocation intersects with a disclination configuration, the force occurs which hampers the dislocation motion. By methods of the elasticity theory the exact formulae are found for the forces,F1andF2, which hamper a moving dislocation intersected with an isolated disclination and a disclination quadrupole, respectively. With the help of these formulae the flow stress of metallic glasses in an inhomogeneous deformation regime as well as the energy of elastic short-range distortions in metallic glasses are estimated within the framework of the model in which basic elements of disclination ensemble in metallic glass are isolated disclinations and disclination quadrupoles.