Thyroid Hormone Action at the Cellular Level
作者:
P. De Nayer,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1987)
卷期:
Volume 26,
issue 1-4
页码: 48-57
ISSN:1663-2818
年代: 1987
DOI:10.1159/000180685
出版商: S. Karger AG
关键词: Triiodothyronine;Nuclear receptors;Hormone action
数据来源: Karger
摘要:
Thyroid hormones influence numerous physiological and biochemical functions. The expression of the hormonal effects involves several events. The interaction of T3 with nuclear receptors, and the stimulation of mRNA production appears to be a major step. Extranuclear binding of thyroid hormones could account for early responses. Plasma membrane receptors may play a role in the cellular uptake of T3 and the stimulation of amino acids and sugar transport. A direct control of oxidative phosphorylation through binding of T3 to mitochondrial binding sites has been proposed. The role of cytosolic binding proteins remains unclear. The understanding of the mode of action of thyroid hormones requires a better knowledge of the molecular events occurring at the nuclear level, and the relation between the nuclear and extranuclear binding sites in the hormonal expression.
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