Flow cytometry: A useful technique in the study of multidrug resistance
作者:
Stéphane Léonce,
Michael Burbridge,
期刊:
Biology of the Cell
(WILEY Available online 1993)
卷期:
Volume 78,
issue 1‐2
页码: 63-68
ISSN:0248-4900
年代: 1993
DOI:10.1016/0248-4900(93)90115-U
出版商: Blackwell Publishing Ltd
关键词: multidrug resistance;P‐glycoprotein;adriamycin;flow cytometry;resistance modulators
数据来源: WILEY
摘要:
Summary—Flow cytometry has recently become a very important tool in the study of the mechanisms of multidrug resistance (MDR). This technique allows rapid access to information regarding two characteristics related to the MDR phenotype: i) the level of overexpression of the P‐glycoprotein; and ii) its functional aspect in expulsion of the cytotoxic agents to which the cell is exposed. In pharmacology, flow cytometry also allows evaluation of the capacity of modulating agents to reverse this resistance, and contributes a deeper insight into the mechanism of action of new molecu
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