ARTERIAL BARORECEPTOR RESETTING: CONTRIBUTIONS OF CHRONIC AND ACUTE PROCESSES
作者:
Michael C. Andresen,
Mingyong Yang,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1989)
卷期:
Volume 16,
issue 1
页码: 19-30
ISSN:0305-1870
年代: 1989
DOI:10.1111/j.1440-1681.1989.tb02993.x
出版商: Blackwell Publishing Ltd
关键词: baroreceptors;blood pressure;genetic hypertension;pressoreceptors
数据来源: WILEY
摘要:
SUMMARY1Pressure threshold (Pth) and suprathreshold pressure sensitivity (Sth) are important measures of the pressure‐discharge characteristics of arterial baroreceptors. Anin vitropreparation of the rat aortic arch‐aortic nerve has been used to assess the influence of extracellular ion concentration, distensibility, smooth muscle activation and rapid resetting on single fibre baroreceptor discharge.2Changes in extracellular cations alter Pth and Sth in a reciprocal manner, suggesting that these two properties share common excitatory mechanisms probably at the level of membrane ion conductance channels.3During normal development and ageing in normotensive rats, Pth and blood pressure are fairly constant even during periods of greatly changing aortic distensibility. Sth increases progressively to maturity and then decreases somewhat with advanced age.4During hypertension, changes in distensibility in spontaneously hypertensive rats do not account for changes in Pth and Sth.5The capacity of arterial baroreceptors to rapidly reset during acute changes in the conditioning mean arterial pressure is not altered by chronic resetting, decreases in distensibility or by differences in the initial Pth or Sth of individual baroreceptors.6Within the maximal physiological or pathophysiological range, the prevailing or conditioning mean arterial pressure appears to be the most potent modulator of arterial baroreceptor discha
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