Suppression of lipolysis in normal man does not inhibit recovery from insuIin‐induced hypoglycaemia
作者:
P. G. NEWRICK,
G. BRAATVEDT,
D. STANSBIE,
R. J. M. CORRALL,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1993)
卷期:
Volume 23,
issue 1
页码: 53-56
ISSN:0014-2972
年代: 1993
DOI:10.1111/j.1365-2362.1993.tb00717.x
出版商: Blackwell Publishing Ltd
关键词: Acipimox;hypoglycaemic recovery;lipolysis
数据来源: WILEY
摘要:
Abstract.Pharmacological suppression of lipolysis is being increasingly used in the treatment of diabetic hyperlipidaemia. Although theoretical hazard of such treatment is that recovery from hypoglycaemia might be impaired. Seven normal subjects were theretore studied on two occasions, following treatment with a single dose of either acipimox 250 mg or placebo. Hypoglycaemic recovery was unaffected, despite effective suppression of plasma non‐esterified fatty acid levels with acipimox. The results suggest that under these conditions activation of lipolysis may not be essential to recovery from hypoglycaemi
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