首页   按字顺浏览 期刊浏览 卷期浏览 ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS
ANOMALOUS EXCHANGE KINETICS OF PEPTIDE AMIDE PROTONS IN AQUEOUS SOLUTIONS

 

作者: ERIC M. KRAUSS,   DAVID COWBURN,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1981）
卷期: Volume 17, issue 1  

页码: 42-47

 

ISSN:0367-8377

 

年代: 1981

 

DOI:10.1111/j.1399-3011.1981.tb01966.x

 

出版商: Blackwell Publishing Ltd

 

关键词: alumichrome;base catalysis of hydrogen exchange;effect of hydrogen‐bonding on peptide hydrogen exchange;gramicidin S;hydrogen exchange rates;oxytocin;peptide conformation

 

数据来源: WILEY

 

摘要:

Reports concerning anomalous rates of exchange of some amides in oxytocin, alumichrome, and gramicidin S are reexamined through systematic analysis of the exchange data as a function of pH and primary structure. It is shown that such an analysis can provide useful information on secondary structure when the degree of hydrogen bonding to both the NH undergoing exchange and the neighboring carbonyl group are taken into consideration.

 

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