SummaryContinuous subcutaneous insulin infusion (CSII) was performed in 3 totally insulin dependent diabetic patients (postprandial C peptide: 0.03±0.01 pmol/l) for periods lasting up to 9 months. During this period, each patient measured his capillary blood glucose 2 to 5 times per day with the Dextrosix(R)/Dextrometer(R)method. A good glycemic control was achieved at home, as assessed by a mean plasma glucose level of±140 mg/dl and a M value ranging from 9 to 24. The mean total glycosylated hemoglobin levels in the 3 patients were 9.3, 9.2 and 11.9% respectively. Hypoglycemic episodes were rarely observed; CSII did not affect the usual way of life of the patients. We did not observe any improvement of the conduction velocy of sciatic nerves, as assessed by electro-myography after a few months of CSII.We conclude that a good glycemic profile can be obtained at home in totally insulin dependent patients with CSII.