192 IgG‐saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN
作者:
Margaret Moga,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 14
页码: 3197-3200
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Circadian rhythm;Hypothalamus;Immunolesion;Immunotoxin;Low-affinity nerve growth factor receptor
数据来源: OVID
摘要:
THE rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR) immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75NTR and VIP immunoreactivity in the rat SCN. The 192 IgG-saporin immunotoxin abolished p75NTR immunoreactivity in the SCN. VIP immunoreactivity in the SCN of saporin-lesioned animals was not significantly different from that of control animals. Immunolesions of the p75NTR-ir cell population in the SCN may prove useful in clarifying the role of p75NTR in circadian timing.
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