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Transforming Growth Factor-βInhibits Lactogenic Hormone Induction ofβ-Casein Expression in HC11 Mouse Mammary Epithelial Cells

 

作者: MiethMaren,   D.Frank,   BallRoland,   GronerBernd,   GrosseRichard,  

 

期刊: Growth Factors  （Taylor Available online 1990）
卷期: Volume 4, issue 1  

页码: 9-15

 

ISSN:0897-7194

 

年代: 1990

 

DOI:10.3109/08977199009011005

 

出版商: Taylor&Francis

 

关键词: Transforming growth factor-β;mammary epithelial cell;β-casein expression;inhibition of functional differentiation

 

数据来源: Taylor

 

摘要:

AbstractHC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms ofβ-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-β(TGF-β) can inhibitβ-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-βalso inhibits DNA synthesis of HC11 cells.These findings suggest a possible role of TGF-βas an inhibitor of functional differentiation in the mammary gland.

 

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