Dramatic recovery of paclitaxel-disabling neurosensory toxicity following treatment with venlafaxine
作者:
Jean-Philippe Durand,
François Goldwasser,
期刊:
Anti-Cancer Drugs
(OVID Available online 2002)
卷期:
Volume 13,
issue 7
页码: 777-780
ISSN:0959-4973
年代: 2002
出版商: OVID
关键词: Antidepressant agent;neuropathy;paclitaxel;pain;venlafaxine
数据来源: OVID
摘要:
Venlafaxine is an antidepressant which acts through the inhibition of the reuptake of norepinephrine and serotonin. Venlafaxine is active against neuropathic and chronic pain. We report the case of a 69-year-old woman who presented a paclitaxel-induced neuropathy. She presented paresthesias, pin pricks in both hands with functional impairment. Venlafaxine hydrochloride was introduced at 37.5 mg twice daily. The patient noticed a dramatic recovery of her symptoms within 2 days, with both reduction of the paresthesias and functional improvement. This is the first report of efficacious use of venlafaxine for the treatment of paclitaxel cumulative neurosensory toxicity.
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