The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na+-Ca2+exchanger (INCX) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions.INCXwas studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increasedINCXat potentials higher than 0 mV (at +60 mV: 2.07±0.22 pA/pF in control versus 2.73±0.22 pA/pF in Ang II, n=9;P<0.05). The increase inINCXinduced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 &mgr;mol/L) (at +60 mV: 2.15±0.27 pA/pF in control versus 2.01±0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II onINCXis the result of the autocrine actions of ET released by the octapeptide.