Pharmacological characterization and differentiation of non‐cholinergic nucleus basalis neuronsin vitro
作者:
Patrice Fort,
Asaid Khateb,
Mauro Serafin,
Michel Mühlethaler,
Barbara Jones,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 1
页码: 61-65
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Acetylcholine;Basal forebrain;Cortex;Histamine;Muscarine;Noradrenaline;Serotonin;Sleep–wake states
数据来源: OVID
摘要:
USING intracellular recordings in guinea pig brain slices, the pharmacology of electrophysiologically identified and immunohistochemically confirmed non-cholinergic nucleus basalis neurons was studied to determine their response to the major neurotransmitters of the subcortical afferents to this region. The cells were differentiated into three types: Type A cells (∼44%) were depolarized by noradrenaline (NA) and muscarine, Type B cells (∼23%) were depolarized by NA but hyperpolarized by muscarine, and Type C cells (∼15%) were hyperpolarized by both agonists. These cell types were also differentially responsive to serotonin (hyperpolarizing B, C) and histamine (depolarizing A, B). Accordingly, the non-cholinergic neurons share certain discharge properties but appear nonetheless to comprise distinct types which respond differentially to the major modulatory neurotransmitters and thus play potentially different roles in cortical modulation across the sleep–wake cycle.
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