Regulation of Aldosterone Secretion in Old Rats
作者:
V.V. Frolkis,
N.S. Verkhratsky,
L.V. Magdich,
期刊:
Gerontology
(Karger Available online 1985)
卷期:
Volume 31,
issue 2
页码: 84-94
ISSN:0304-324X
年代: 1985
DOI:10.1159/000212685
出版商: S. Karger AG
关键词: Hypothalamus;Pituitary;Rat;Regulation;Mineralocorticoid receptors;Aldosterone secretion
数据来源: Karger
摘要:
The experiments on adult (4–6 months) and old (28–30 months) rats revealed changes that develop in old age in various links of the regulatory system of aldosterone secretion: the hypothalamic-hypophyseal control of mineralocorticoid secretion decreased, and the sensitivity of the glomerular zone to ACTH, vasopressin, and K+, as well as that of the myocardium, skeletal muscle and kidney to aldosterone increased. Changes in tissue sensitivity to aldosterone may be due to the increased affinity of mineralocorticoid receptors to aldosterone in old
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