Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia
作者:
Larry R Sherman,
Friedo Huber,
期刊:
Applied Organometallic Chemistry
(WILEY Available online 1988)
卷期:
Volume 2,
issue 1
页码: 65-72
ISSN:0268-2605
年代: 1988
DOI:10.1002/aoc.590020109
出版商: Longman Group UK Ltd.
关键词: Organotin compounds;P388 leukemia;cytotoxicity;thymus gland
数据来源: WILEY
摘要:
AbstractCytotoxicity of organotin compounds is assessed and their effectiveness against leukemia is discussed. The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic effect upon the thymus gland are the tri‐n‐butyltin, di‐n‐butyltin, tri‐n‐propyltin and di‐n‐octyltin groups. Compounds containing these groups also exhibit the poorest test‐control ratio (T/C) values when tested as anti‐cancer agents against leukemic mice
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