Brain Metastasis from Nonseminomatous Germ Cell Tumors of the Testis: Case Report and Review of the Role of Surgery
作者:
Richard Jelsma,
Michael Carroll,
期刊:
Neurosurgery
(OVID Available online 1989)
卷期:
Volume 25,
issue 5
页码: 814-819
ISSN:0148-396X
年代: 1989
出版商: OVID
关键词: Brain metastasis;Chemotherapy;Nonseminomatous germ cell tumor of the testis;Radiation therapy;Surgical treatment
数据来源: OVID
摘要:
&NA;The prognosis for patients with nonseminomatous germ cell tumor of the testis is good, even when extensive metastatic disease is present, because this tumor is very sensitive to chemotherapy with cisplatin, vinblastine, and bleomycin (PVB). If a metastasis occurs in the brain, however, the prognosis is poor because the blood‐brain barrier limits the entrance of these drugs into the brain and creates a sanctuary for tumor. The current treatment for a brain metastasis is either standard PVB chemotherapy plus whole brain radiation therapy or a rigorous chemotheraputic regimen that penetrates the blood‐brain barrier better than PVB. Surgery is seldom used for brain metastasis, largely because of the poor results with surgical debulking in noncentral nervous system disease. This is the report of a patient with disseminated nonseminomatous germ cell tumor and multiple large brain metastases, who was treated with surgery, PVB, and whole brain radiation therapy and cured. Evidence is presented to support a role for surgical debulking in patients with large brain metastasis. (Neurosurgery25:814—819, 1989)
点击下载:
PDF
(4147KB)
返 回