Complications of Low-Dose Heparin Prophylaxis in Gynecologic Oncology Surgery
作者:
DANIEL CLARKE-PEARSON,
E R DeLONG,
INGRID SYNAN,
WILLIAM CREASMAN,
期刊:
Obstetrics & Gynecology
(OVID Available online 1984)
卷期:
Volume 64,
issue 5
页码: 689-694
ISSN:0029-7844
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
The clinical and laboratory effects of low-dose heparin prophylaxis was prospectively studied in a controlled trial of 182 patients undergoing major surgery for gynecologic malignancy. Low-dose heparin was given in 5000 U subcutaneously two hours preoperatively and every 12 hours for seven days postoperatively. Low-dose heparin-treated patients had a significantly increased daily retroperitoneal hemovac drainage. Although not statistically significant, low-dose heparin was associated with increased estimated intraoperative blood loss, transfusion requirements, and wound hematomas. Fifteen percent of patients receiving low-dose heparin were found to have an activated partial thromboplastin time greater than 1.5 times the control value. In these patients, all clinical bleeding parameters were significantly increased. Low-dose heparin-treated patients also had significantly prolonged activated partial thromboplastin time and lower final platelet counts as compared with the control patients. When using low-dose heparin for thromboembolism prophylaxis, patients should be closely observed for clinical hemorrhagic complications. Activated partial thromboplastin times and platelet counts should be monitored throughout therapy.
点击下载:
PDF
(479KB)
返 回