The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement
作者:
ShengTsann,
ReenChrong,
WangGeng,
LoonGwon,
YuanMao,
RenGong,
TangKuei,
YenChe,
YenChen,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 18,
issue 3
页码: 169-175
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409007993
出版商: Taylor&Francis
关键词: Anticardiolipin antibody;Interleukin-6;systemic lupus erythematosus
数据来源: Taylor
摘要:
Anticardiolipin (ACL) antibodies and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) may be involved in the mechanism of lupus patients with central nervous system (CNS) involvement. ACL antibodies of 3 isotypes and IL-6 were measured in paired CSF and serum samples from 14 lupus patients with CNS involvement, 5 lupus patients without CNS involvement and 7 patients with non-inflammatory neurological diseases. ACL antibodies, IgG and IgM isotypes, and IL-6 were significantly increased in CSF from lupus patients with CNS involvement as compared with other 2 groups of patients. Both ACL antibodies and IL-6 decreased after neurological activity subsided. These results suggest increased ACL antibodies and IL-6 in CSF are involved in immune responses within CNS in lupus patients. Quantitation of CSF ACL antibodies may be helpful in evaluating neurological activity of lupus patients with CNS involvement.
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