Immunohistochemical Localization of Pregnancy–Related Placental Protein 4 in Nontumorous Tissues and in Gynecological Tumors
作者:
P.M. Gocze,
R. Jozsa,
D.G. Szabo,
H. Bohn,
D.A. Freeman,
期刊:
Tumor Biology
(Karger Available online 1994)
卷期:
Volume 15,
issue 4
页码: 203-209
ISSN:1010-4283
年代: 1994
DOI:10.1159/000217893
出版商: S. Karger AG
关键词: Immunohistochemical;Localization;Pregnancy-related placental;protein 4;Gynecological tumor;Tumor marker
数据来源: Karger
摘要:
The aim of the study was to demonstrate the localization of placental protein 4 (PP4) in different nontumorous and tumorous tissues originating from the female genital tract. PP4 immunoreactivity was demonstrated using the peroxidase-antiperoxidase immunohistochemical technique. Tissue samples were obtained from the cervix and body of the uterus, ovary, vulva and from gestational trophoblastic tumors. PP4-positive cells were present in nontumorous tissues with various pathologic findings, and in many but not all benign gynecological tumors. Similar numbers of PP4-positive cells were located in malignant and benign gynecological tumors; however, PP4 staining intensity was greater in the malignant lesions. PP4-positive cells were found in hydatidiform moles and in choriocarcinoma. PP4 was distributed mainly in the cytoplasm, but it was also bound to the cell membrane. We conclude from these studies that PP4 is located in a variety of benign and malignant cells of the female genital tract and that these cells may be the source of plasma PP4 found in patients with these conditions.
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