Hemoglobin Hofu orαβ[126 (H4) Val→Glu] Found in Combination with Hemoglobin S
作者:
BrittenhamG.,
LozoffB.,
HarrisJ. W.,
NayuduN. V. S.,
GravelyM.,
WilsonJ. B.,
LamH.,
HuismanT. H. J.,
期刊:
Hemoglobin
(Taylor Available online 1978)
卷期:
Volume 2,
issue 6
页码: 541-549
ISSN:0363-0269
年代: 1978
DOI:10.3109/03630267809005355
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Hb Hofu,αβ[126 (H4) Val→Glu], was found in 10 members of 2 apparently unrelated Valmiki families in central India. None showed evidence of hemolysis and hemoglobin levels were normal in most. In two individuals, Hb Hofu occurred in combination with Hb S, but neither had clinical manifestations of sickle cell disease. In samples containing Hb Hofu, the isopropanol precipitation test was positive. Quantitation of the hemoglobin fractions by DEAE-cellulose chromatography showed that Hb Hofu constituted a mean of 23-25% of the total whether in combination with Hb A or Hb S.
点击下载:
PDF (326KB)
返 回