PARADOXICAL CARDIOVASCULAR RESPONSE TO VISCERAL AFFERENT STIMULATION IN THE ESTABLISHED SPONTANEOUSLY HYPERTENSIVE RAT
作者:
Shozo Koyama,
John W. Manning,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1985)
卷期:
Volume 12,
issue 1
页码: 37-42
ISSN:0305-1870
年代: 1985
DOI:10.1111/j.1440-1681.1985.tb00300.x
出版商: Blackwell Publishing Ltd
关键词: blood pressure;clonidine;spontaneously hypertensive rat;sympathoinhibitory pathway;visceral afferent stimulation.
数据来源: WILEY
摘要:
SUMMARY1. Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed.2. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation.3. It is suggested that the central integrated mechanisms for activating a cardiovascular state change as evoked by visceral afferents may differ in the established hypertensive rat from that of the normotensive.
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