Electrochemical Studies of Tirapazamine: Generation of the One-Electron Reduction Product
作者:
TocherJoanne H.,
EdwardsD. I.,
期刊:
Free Radical Research
(Taylor Available online 1994)
卷期:
Volume 21,
issue 5
页码: 277-283
ISSN:1071-5762
年代: 1994
DOI:10.3109/10715769409056580
出版商: Taylor&Francis
关键词: Tirapazamine;benzotriazine-N-oxides;voltammetry;anion radical
数据来源: Taylor
摘要:
The electrochemical properties of the benzotriazine di-N-oxide, tirapazamine (SR4233), and the mono-and zero-N-oxides, SR4317 and SR4330 respectively, have been investigated in dimethylformamide and acetonitrile. The voltammetry of tirapazamine is complicated, with up to 6 reduction steps being identified, depending on the solvent. Both SR4317 and SR4330 show two reduction steps. The first reduction of all three compounds is a reversible or quasi-reversible step, which is assigned to a 1-electron addition. Cyclic voltammetric studies show that the anion radical product is stable, although the tirapazamine 1-electron addition product shows a tendency to participate in a chemical following reaction. Subsequent reduction steps are all highly irreversible in nature. The 2nd electron transfer of SR4317 results in the formation of the free base, SR4330, which is identified voltammetrically. Comparison is made with the voltammetric behaviour of quinoline and quinoline-oxide.
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