Whether the extent of dry weight inhibition by nitrogen (N) or phosphorus (P) deficiencies on different plant parts is the same and whether imposing moderate N and P deficiencies selectively suppress undesirable vegetative growth has not been studied in Pima cotton(Gossypium barbadenseL.). The purpose of this study was to determine the extent to which dry matter accumulation in leaves, stems, and reproductive structures is inhibited by N and P deficiencies in Pima cotton. The study was conducted in 1991 and 1992 in a Uvalde silty clay loam soil (fine‐silty, mixed, hyperthermic Aridic Calciustolls). The treatments included applied rates of 0, 67, 135, 202, and 269 kg N ha‐1in a factorial combination with 0, 15, 29, and 44 kg P ha‐1. Nitrogen deficiency (0 kg N ha‐1) significantly (P≤0.05) reduced leaf (LDW) and stem (SDW) dry weights in both years and reproductive dry weight (RDW) in 1992. Nitrogen deficiency suppressed dry weight accumulation in leaves to a greater extent than in stems. Relative to 269 kg N ha‐1, the 0 kg N ha‐1treatment resulted in a maximum LDW reduction of 62% at 144 DAP (days after planting) in 1991 and 36% at 121 DAP in 1992, compared with a corresponding SDW reduction of only 39% in 1991 and 25% in 1992. Dry weight accumulation in reproductive parts was the least affected by N deficiency. The decline in LDW associated with senescence and defoliation began earlier in treatments that received 0 or 67 kg N ha‐1than treatments that received ≥135 kg N ha‐1. Phosphorus affected LDW and SDW in 1991, but its differential effect on LDW, SDW, and RDW was much smaller than that of N. Imposing a moderate level of N deficiency, not P deficiency, may be an effective Pima cotton management strategy to selectively suppress undesirable vegetative growth and enhance maturity.