Sulphamethoxazole-Trimethoprim: Effect on Antibody Response in Man
作者:
H. Arvilommi,
M. Vuori,
A. Salmi,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 1
页码: 37-42
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221908
出版商: S. Karger AG
关键词: Sulphamethoxazole-trimethoprim;Antibody response;Immuno-suppression;Human
数据来源: Karger
摘要:
The possible immunosuppressive properties of the combination sulphamethoxazole-trimethoprim or either of the agents alone were studied in healthy human volunteers. The effect of the 4-day drug treatment on the antibody synthesis after vaccination was measured by titrating tetanus antitoxin, mumps antibody and Salmonella Hb antibody levels 4 and 5 weeks after vaccination. No significant differences were found in mumps or Salmonella antibody titres in the drug-treated group compared to controls. Tetanus antitoxin levels, however, were significantly lower than in controls after the combined drug. When a fourfold or greater increase in tetanus antitoxin titre was obtained in 75% of controls, the respective figures were 38% in the sulphamethoxazole-trimethoprim-treated group (p 0.05). The implications of these findings are discussed.
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