Integrin‐mediated calcium signaling and regulation of cell adhesion by intracellular calcium
作者:
Michael D. Sjaastad,
W. James Nelson,
期刊:
BioEssays
(WILEY Available online 1997)
卷期:
Volume 19,
issue 1
页码: 47-55
ISSN:0265-9247
年代: 1997
DOI:10.1002/bies.950190109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractIntegrins are ubiquitous trans‐membrane adhesion molecules that mediate the interaction of cells with the extracellular matrix (ECM). Integrins link cells to the ECM by interacting with the cell cytoskeleton. In cases such as leukocyte binding, integrins mediate cell‐cell interactions and cell‐ECM interactions. Recent research indicates that integrins also function as signal transduction receptors, triggering a number of intracellular signaling pathways that regulate cell behavior and development. A number of integrins are known to stimulate changes in intracellular calcium levels, resulting in integrin activation. Although changes in intracellular calcium regulate a vast number of cellular functions, this review will discuss the stimulation of calcium signaling by integrins and the role of intracellular calcium in the regulation of integrin‐mediated a
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