ALTERATIONS OF MALE WISTAR RAT JEJUNUM INDUCED BY DODINE (n-DODECYLGUANIDINE ACETATE)
作者:
M. Mitjans,
M. P. Vinardell,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1997)
卷期:
Volume 52,
issue 6
页码: 545-556
ISSN:0098-4108
年代: 1997
DOI:10.1080/00984109708984080
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The effect of Dodine on the intestine was studied after a single administration of 1000 mg/kg, which corresponds to the LD50 in male Wistar rats. At this dose, a significant decrease in body weight was observed, accompanied by diarrhea, which may be associated with intestinal alterations. The chemical induced a significant reduction of the protein con tent and in sucrase activity in the jejunum. Morphological alterations included a significant decrease in crypt height and in villus length and depth. The intestinal modifications observed in animals after Dodine administration may explain the observed loss in body weight and diarrhea.
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