Huntington's Disease: Current Concepts of Therapy*
作者:
CHRISTOPHER G. GOETZ,
WILLIAM J. WEINER,
期刊:
Journal of the American Geriatrics Society
(WILEY Available online 1979)
卷期:
Volume 27,
issue 1
页码: 23-26
ISSN:0002-8614
年代: 1979
DOI:10.1111/j.1532-5415.1979.tb01716.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
ABSTRACT:Huntington's disease (Huntington's chorea), a degenerative disorder of the central nervous system, is inherited in an autosomal dominant pattern. Since there is no cure for this genetic disorder, therapy has been focused on pharmacologic manipulation of the involved neurotransmitter systems. In Huntington's disease, there is a functional predominance of striatal dopaminergic activity over antagonist cholinergic and possiblygaba‐minergic systems. Many dopaminergic antagonists and cholinergic andgaba‐minergic agonists are currently used in treatment. Supportive psychiatric care for affected persons and their families is an important therapeutic adjunct in the management of Huntington's disease. The eventual therapy will depend upon accurate identification of the primary genetic def
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