Malabsorption of Hydrochlorothiazide Following Intestinal Shunt Surgery
作者:
L. Backman,
B. Beerman,
M. Groschinsky-Grind,
D. Hallberg,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1979)
卷期:
Volume 4,
issue 1
页码: 63-68
ISSN:0312-5963
年代: 1979
出版商: ADIS
数据来源: ADIS
摘要:
Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml · h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery.
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