We report a case of a diabetic renal transplant patient with candiduria who developed repeated elevations in serum creatinine concentration due to an intermittently obstructing Candida ball in the urinary tract. After unsuccessful attempts to place a nephrostomy tube for local irrigation and debulking, the renal graft artery ruptured secondary to extensive perirenal Candida infection. Percutaneous nephrostomy may increase the risks of renal and extrarenal tissue infection with the potential for fatal complications such as infection of the vascular anastomosis.