Effect of organic synthetic food colours on mitochondrial respiration
作者:
F. G. R. Reyes,
M. F. C. F. A. Valim,
A. E. Vercesi,
期刊:
Food Additives & Contaminants
(Taylor Available online 1996)
卷期:
Volume 13,
issue 1
页码: 5-11
ISSN:0265-203X
年代: 1996
DOI:10.1080/02652039609374376
出版商: Taylor & Francis Group
关键词: food colours;mitochondria;oxygen uptake
数据来源: Taylor
摘要:
Eleven organic synthetic dyes, currently or formerly used as food colours in Brazil, were tested to determine their effect on mitochondrial respiration in mitochondria isolated from rat liver and kidney. The compounds tested were: Erythrosine, Ponceau 4R, Allura Red, Sunset yellow, Tartrazine, Amaranth, Brilliant Blue, Indigotine Blue, Fast Red E, Orange GGN and Scarlet GN. All food colours tested inhibited mitochondrial respiration (State III respiration, uncoupled) supported either by α‐ketoglutarate or succinate. this inhibition varied largely, e.g. from 100% to 16% for Erythrosine and Tartrazine respectively, at a concentration of 0.1 mg food colour per mitochondrial protein. Both rat liver and kidney mitochondria showed similar patterns of inhibition among the food colours tested. This effect was dose related and the concentration to give 50% inhibition was determined for some of the dyes. The xanthene dye Erythrosine, which showed the strongest effect, was selected for further investigation on mitochondriain vivo.
点击下载:
PDF (357KB)
返 回