Use of polymerase chain reaction for the early detection of HIV infection in the infants of HIV‐seropositive women
作者:
Peggy Weintrub,
Paul Ulrich,
John Edwards,
Francois Boucher,
Jay Levy,
Morton Cowan,
Girish Vyas,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 7
页码: 881-884
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Polymerase chain reaction;HIV.
数据来源: OVID
摘要:
Forty-two infants of HIV-seropositive women were evaluated to determine the value of polymerase chain reaction (PCR) in the early detection of HIV infection. All infants less than 6 months old had a simultaneous PCR and culture for HIV. There was an 88% concordance between the two techniques. PCR results showed an excellent correlation with clinical outcome; no PCR-negative patient has subsequently been found to be infected. Occasional false-positive or equivocal PCR results did occur. There was one false-negative culture. PCR is a rapid and sensitive diagnostic test for the early diagnosis of HIV infection in infants at risk, but at present it should be performed in conjunction with other diagnostic tests and good clinical follow-up.
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