Relationships betweenin vitroSusceptibility and Efficacy in Experimental Mouse Infection-Protection Assay of Cefazolin and Cephalothin usingEscherichia coliStrains
作者:
Joseph V. Uri,
Paul Actor,
Lillian Phillips,
Joseph R. Guarini,
Jerry A. Weisbach,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 5
页码: 313-318
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221938
出版商: S. Karger AG
关键词: Cefazolin;Cephalothin;Disc sensitivity ofE. colistrains;MIC values ofE. colistrains;E. coliinfection of mice;ED50values in mice;Relationships betweenin vitroandin vivo<
数据来源: Karger
摘要:
The disc sensitivity and minimal inhibitory concentrations (MIC) of cefazolin and cephalothin were compared against a series of Escherichia coli isolates. These data were correlated with the mouse protective doses of the 2 cephalosporins in animals infected with E. coli strains selected according to their various degrees of in vitro sensitivity to the 2 cephalosporins. The overwhelming majority of E. coli strains showed a significantly higher degree of susceptibility and lower MIC values for cefazolin than for cephalothin. There has been found a good correlation between the inhibition zones and especially the MIC values and the ED50 results for both cephalosporins. Using E. coli clinical isolates, cefazolin was found to be superior to cephalothin not only in vitro experiments but also more potent in protecting the experimentally infected mice.
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