Influence of Magnesium Deficiency on Concentration of Calcium in Soft Tissue of Uremic Rats
作者:
InagakiOshi,
SyonoTadayasu,
NakagawaKiyohiko,
NishianYoshihiko,
TakenakaYosiaki,
TakamitsuYoshihiro,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 6
页码: 847-854
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609047711
出版商: Taylor&Francis
关键词: Calcification;Calcium;Magnesium;Uremia
数据来源: Taylor
摘要:
The influence of magnesium (Mg) deficiency on the concentration of calcium (Ca) in the aorta, heart, and kidney was evaluated in uremic rats. A total of 32 rats were randomly assigned to two groups: one group made uremic by the 5/6 nephrectomy method, and the other serving as sham-operated controls. Both groups were randomly assigned to two subgroups: one group given a Mg-deficient diet and the other fed a Mg-supplemented diet. After 12 weeks on the regimen, all animals were sacrificed. In Mg-supplemented uremic rats, the concentration of Ca in the aorta was higher than in Mg-supplemented control rats. The concentration of Ca in the aorta was further increased in Mg-deficient uremic rats. The concentrations of Ca in the heart and the kidney were also increased in Mg-deficient uremic rats, as compared with Mg-supplemented uremic rats. The concentration of Mg was decreased in the aorta and increased in the kidney of Mg-deficient rats. There was no significant influence of Mg deficiency on the concentration of phosphate in tissue. Results suggest that Mg deficiency in uremia may increase aortic calcification.
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