Simple nonsingular control approach to fed‐batch fermentation optimization
作者:
J. M. Modak,
H. C. Lim,
期刊:
Biotechnology and Bioengineering
(WILEY Available online 1989)
卷期:
Volume 33,
issue 1
页码: 11-15
ISSN:0006-3592
年代: 1989
DOI:10.1002/bit.260330103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractDetermination of the optimal feed rate for fed‐batch fermentation is normally a problem in singular control with a state inequality constraint and as such is, in general, difficult to solve, especially for those described by a large number of dynamic mass balance equations. In this article we use a new set of state variables and the culture volume as the control variable. In this way the problem is converted to one of nonsingular control with the magnitude and rate constraints on the manipulated variable and can be numerically solved by a gradient‐based technique, thus avoiding the difficulty associated with singular control problems. Examples are given to illustrate the met
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