Effects of Prazosin HCl on Micturition Disturbance Associated with Benign Prostatic Hypertrophy and Bladder Neck Contracture
作者:
Yoshiteru Kohama,
Hironobu Watanabe,
Yasukazu Sen,
Yukio Yamamoto,
Masaaki Morioka,
Yukitoshi Fujita,
期刊:
Urologia Internationalis
(Karger Available online 1990)
卷期:
Volume 45,
issue 1
页码: 26-29
ISSN:0042-1138
年代: 1990
DOI:10.1159/000282026
出版商: S. Karger AG
关键词: Prazosin HCl;Uroflowmetry;Flow rate nomogram;Calculated minimum time of micturition;Benign prostatic hypertrophy
数据来源: Karger
摘要:
The effects of α1-adrenergic blockade with prazosin HCl were examined in 28 patients with benign prostatic hypertrophy and bladder neck contracture. The patients received 2–3 mg of prazosin HCl daily administered orally. Improvement in subjective symptoms was observed in 75% of the patients. We evaluated clinical effects as the minimum time of micturition (calculated as the ratio of voided volume/maximum flow rate) for voided volumes less than 200 ml and the maximum flow rates and average flow rates for voided volumes over 200 ml. Evaluation of the findings on a flow rate nomogram revealed improvement in maximum flow rates and average flow rates in 41% of the patients. Side effects such as dizziness developed in only 1 patie
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